PATENT-Cannabinoids as Antioxidants and Neuroprotectants

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Publication number US6630507 B1
Publication type Grant
Application number US 09/674,028
PCT number PCT/US1999/008769
Publication date 7 Oct 2003
Filing date 21 Apr 1999
Priority date 21 Apr 1998
Fee status Paid
Also published as CA2329626A1, 4 More »
Inventors Aidan J. Hampson, Julius Axelrod, Maurizio Grimaldi
Original Assignee The United States Of America As Represented By The Department Of Health And Human Services
Export Citation BiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Cannabinoids as antioxidants and neuroprotectants
US 6630507 B1
Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. A particular disclosed class of cannabinoids useful as neuroprotective antioxidants is formula (I) wherein the R group is independently selected from the group consisting of H, CH3, and COCH3.

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