Cannabidiol (CBD): Fighting Inflammation & Aggressive Forms of Cancer

Janet Medical Research

 

Cannabis contains at least 60 known chemicals called cannabinoids, which activate naturally occurring cannabinoid receptors in your body.

Tetrahydrocannabinol, or THC, is the main component responsible for the psychoactive effects, or “high,” cannabis is known for. While THC is known to have some medicinal value, there has been recent investigation into a new cannabinoid that is rumored to have more medicinal benefits than any single pharmaceutical drug on the market.

What is Cannabidiol (CBD)?

This cannabinoid is known as Cannabidiol (CBD), and is the second most abundant cannabinoid in cannabis. Research done by G.W. Pharmaceuticals suggests that CBD could be used for treating symptoms of rheumatoid arthritis and other autoimmune diseases, diabetes, nausea, bowel disorders, and many other hard-to-control side effects. According to an article from Projectcbd.com, CBD has even demonstrated neuroprotective effects, and its anti-cancer potential is currently being explored.

While it was originally believed that THC is a breakdown product of CBD, it is now known that both THC and CBD are actually metabolites of their decarboxylated acidic forms, THCa and CBDa. These acidic precursors are decarboxylated (essentially dried) by heat or extraction to produce THC and CBD; only then do they become psychoactive. The compound has medicinal benefits without the “high” that some patients do not desire. This makes CBD appealing to patients who are looking for an alternative to their current meds, which often have opiate-like effects.

“After years of growers aiming to boost THC percentages in their crops, many growers have switched to focusing on producing CBD-rich strains because of the increasing demand by medical users.”

Cannabidiol is even known to counteract some of the effects of THC like the “munchies.” Just as THC increases our appetite, CBD suppresses it, which could be ideal for patients watching their figure. CBD just might be a key ingredient in a future weight loss drug, who knows?

There is one exception to the theory that CBD suppresses appetite, but it is a blessing as well. Many people who have difficulty eating due to their stress or anxiety can use CBD to get rid of that sick feeling in their chest or stomach, allowing them to eat again once their anxiety subsides.

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A recent study published in The International Journal of Neurophamacology points to Cannabidiol (CBD) as a cause of Neurogenesis in the brain; specifically in the Hippocampus, an area typically associated with conscious memory and navigation. However, the researchers believe that CBD’s anxiety relief may be due to this neurogenesis in the brain. You can read our full article on the study here.

CBD Treats A Number of Symptoms

Cannabidiol is what gives cannabis its sedative effect, and has been known to ease a number of symptoms from difficult conditions.  There has actually been a substantial amount of experiments done on cannabidiol that has proved its healing powers.

Dr. Sean McAllister, a scientist from the Pacific Medical Center in San Francisco, made an astounding discovery about CBD. McAllister has been studying cannabinoid compounds for 10 years now in search of new therapeutic interventions for various cancers. He discovered that cannabidiol is a potent inhibitor of cancer cell proliferation, metastasis, and tumor growth.

Results of his experiments on breast cancer show that the number of cancer cells diminished as more CBD was applied. Essentially, CBD may be a generally effective way to switch off the cancer-causing gene, providing patients with a non-toxic therapy to treat aggressive forms of cancer.

“CBD could be used for treating symptoms of rheumatoid arthritis and other autoimmune diseases, diabetes, nausea, bowel disorders, and many other hard-to-control side effects.”

Raphael Mechoulam of the Hebrew University, Jerusalem, and Faculty of Medicine has been studying cannabinoids for almost 50 years. Mechoulam gave a talk on cannabidiol on the 45th year of involvement in the field in which he spoke about a number of experiments being done on cannabidiol.

He described an experiment that was done in Brazil in which a 200mg/day dosage of CBD was added to the anticonvulsants epilepsy patients were currently taking. Over the course of several months only 1 of the 7 patients showed no improvement; three became seizure-free; one experienced only one or two seizures, and two experienced reduced severity and occurrence of seizures.

CBD Is An Anti-Inflamatory & Prevents Diabetes

A colleague of Mechoulam’s, Marc Feldman at Imperial College, London, tested CBD on mice that had a version of rheumatoid arthritis. He found that CBD reduced the mice’s inflammation by 50% at the right dosage. Cardiologists working with the mice at Hebrew University have found that a dosage of CBD immediately following a heart attack can reduce infarct size by about 66%.

“CBD did not just prevent onset, it blocked the development of diabetes.” – Raphael Mechoulam 

Another notable study conducted by Mechoulam was done on mice bred to have a version of type-1 diabetes. The diabetes was designed to manifest right around 14 weeks, so the mice were treated with CBD for the first 7 weeks of their life and then again in another 7 weeks. He concluded that only 30% had developed diabetes compared to the 90-100% given the placebo.

He then repeated the experiment where the CBD wasn’t introduced until 14 weeks when the diabetes first developed. They were then tested at 24 weeks of age and again only 30% of the treated mice were found to have diabetes. “CBD did not just prevent onset,” said Mechoulam, “it blocked the development of diabetes.”

 

Inflammation Triggers the Symptoms of Disease

The presence of inflammation is what makes most disease perceptible to an individual. It can and often does occur for years before it exists at levels sufficient to be apparent or clinically significant. How long it has been smoldering really determines the degree of severity of a disease and often the prognosis assuming the inflammation can be controlled. One could also argue that without inflammation most disease would not even exist. Take a look at this list of diseases and their relationship with inflammation:

Disease Mechanism
Allergy 4 Immune Mediated Types + Sensitivities, all of which cause inflammation
Alzheimer’s Chronic inflammation destroys brain cells
Anemia Inflammatory cytokines attack erythropoietin production
Ankylosing Spondylitis Inflammatory cytokines induce autoimmune reactions against joint surfaces
Asthma Inflammatory cytokines induce autoimmune reactions against airway lining
Autism Inflammatory cytokines induce autoimmune reactions in the brain arresting right hemisphere development
Arthritis Inflammatory cytokines destroy joint cartilage and synovial fluid
Carpal Tunnel Syndrome Chronic inflammation causes excessive muscle tension shortening tendons in the forearm and wrist compressing the nerves.
Celiac Chronic immune mediated inflammation damages intestinal lining
Crohn’s Disease Chronic immune mediated inflammation damages intestinal lining
Congestive heart failure Chronic inflammation contributes to heart muscle wasting
Eczema Chronic inflammation of the gut and liver with poor detoxification and often antibodies against Transglutaminase-3.
Fibromyalgia Inflamed connective tissue often food allergy related and exacerbated by secondary nutritional and neurological imbalances.
Fibrosis Inflammatory cytokines attack traumatized tissue
Gall Bladder Disease Inflammation of the bile duct or excess cholesterol produced in response to gut inflammation
GERD Inflammation of the esophagus and digestive tract nearly always food sensitivity and pH driven
Guillain-Barre Autoimmune attack of the nervous system often triggered by autoimmune response to external stressors such as vaccinations.
Hashimoto’s Thyroiditis Autoimmune reaction originating in the gut triggered by antibodies against thyroid enzymes and proteins
Heart attack Chronic inflammation contributes to coronary atherosclerosis
Kidney failure Inflammatory cytokines restrict circulation and damage nephrons and tubules in the kidneys
Lupus Inflammatory cytokines induce an autoimmune attack against connective tissue
Multiple Sclerosis Inflammatory cytokines induce autoimmune reactions against myelin
Neuropathy Inflammatory cytokines induce autoimmune reactions against myelin and vascular and connective tissues which irritate nerves.
Pancreatitis Inflammatory cytokines induce pancreatic cell injury
Psoriasis Chronic inflammation of the gut and liver with poor detoxification
Polymyalgia Rheumatica Inflammatory cytokines induce autoimmune reactions against muscles and connective tissue
Rheumatoid Arthritis Inflammatory cytokines induce autoimmune reactions against joints
Scleroderma Inflammatory cytokines induce an autoimmune attack against connective tissue
Stroke Chronic inflammation promoted thromboembolic events
Surgical complications Inflammatory cytokines (often pre-dating the surgery) slow or prevent healing

 

CBD-Rich Strains Making A Comeback

Unfortunately most commercially available indica strains have been selected and bred for their high levels of THC for the past 20-30 years. This has resulted in CBD being nearly bred out of the plant — most strains contain less than 1% CBD.

Since CBD typically shows up under 1% in most strains, it is sometimes hard to find a plant with equally as low THC percentages as to avoid the ‘high’ patients experience from THC. However, that doesn’t mean that these CBD-rich strains don’t exist!

Thanks to the many growers who are now focusing on CBD-rich strains for their medicinal benefits rather than seeking a high from sticky THC-covered strains, CBD-rich strains are making a comeback.

Cannatonic” is one known popular CBD-rich strain which is known to contain 6.5% CBD by weight, and the same amount of THC, making for one of the most medicinal strains out there. Sour Tsunami, Ghost RiderHarlequin, Jamaican Lion and Omrita Rx3 have been tested several times by several labs as high as 18% CBD with equal or lower percentages of THC (3:2 ratio of CBD to THC in most cases).

We have only begun to scratch the surface of understanding this miraculous cannabinoid. While significant discoveries have been made about the medicinal benefits of Cannabidiol, there is much left to reveal about this cannabinoid. You can read about recent developments in ProjectCBD.org’s CBDiary, a catch-all column for news generated by patients, doctors, dispensaries, growers, plant breeders, pharmacologists, the industry, the government —all the players— as the CBD story unfolds.

Helpful Cannabidiol (CBD) Resources and Article Sources:

Article by: Zach Reichard

Posted at:  http://www.medicaljane.com/2012/12/20/cannabidiol-cbd-medicine-of-the-future/#